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After six seasons of fabulous shoes, killer clothes and naughty talk, newspaper columnist Carrie Bradshaw and her risque buddies will say goodbye to New York: HBO’s “Sex and the City” is calling it a series.

The Emmy-winning series about the Manhattan-based relationship escapades of Bradshaw (Sarah Jessica Parker) and her friends–cynical lawyer Miranda Hobbes (Cynthia Nixon), demure former art gallery owner Charlotte York (Kristin Davis) and racy public relations executive Samantha Jones (Kim Cattrall)–will begin work on its final season at the end of March.

A total of 20 episodes will be made, 12 to air this summer, and the remaining eight to broadcast starting next January.

The exit for “Sex,” which won a best-comedy Emmy in 2001, means HBO in 2004 will be without its signature comedy and drama series–“The Sopranos” is supposedly also ending its run after its fifth season, which is scheduled to begin sometime in September.

Hoping to fill part of that void is “Deadwood,” a western set in a lawless town in South Dakota circa 1876. It comes from David Milch, co-creator of “NYPD Blue,” and will feature a mix of fictional and real characters (including Keith Carradine as Wild Bill Hickok).

Meanwhile, another acclaimed HBO series returns for a third season on March 2: “Six Feet Under,” the surreal comedy-drama about a family-run funeral business, which has won six Emmys and two Golden Globes. The pay-cable network is also bringing back for another season “The Wire,” last summer’s alluring crime drama about the police investigation of a Baltimore drug operation.

“Politically Incorrect” host Bill Maher’s new HBO current-events talk show “Real Time” premieres Feb. 21. Finally, the sixth (and last) season finale of gritty prison drama “Oz” is a 100-minute episode scheduled for Feb. 23.